Director
Madrigal · Waltham, Massachusetts · On-site
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Manage U.S. tax operations and ASC 740 reporting for a public biopharmaceutical company.
Worth knowing: Leads tax technology implementations and SOX controls for audit readiness.
Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. Reporting to the Executive Director, Tax, the Associate Director, U.S. Tax Operations & Reporting will be accountable for Madrigal’s U.S. tax operations and global tax reporting infrastructure, including ASC 740 tax reporting, U.S. compliance, financial statement and tax authority audit readiness, SOX-aligned controls, tax technology enablement, and external advisor management. This hands-on role requires a tax professional who can independently drive work from planning through execution, deliver audit-ready work product, bring clear recommendations to senior leadership, and translate complex tax matters into practical business guidance for Finance and business partners. Key Outcomes for Success Deliver accurate, timely, audit-ready quarterly and annual tax reporting under ASC 740, including the tax provision, UTPs, effective tax rate, Form 10-K/10-Q disclosures, and documentation supporting key judgments. Convert tax risks and technical analyses into concise recommendations, options, and decision points for senior leadership and business partners. Build capacity and operational leverage within the Tax function by leading external advisors and cross-functional workstreams with clear priorities, accountability, and continuous improvement.
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